In a prison for the criminally insane, deranged anthropologist Ethan Powell is set to be examined by a bright young psychiatrist, Theo Caulder. Driven by ambition and a hunger for the truth, Caulder will eventually risk everything — even put his very life on the line — in a harrowing attempt to understand the bizarre actions of this madman.

Jacques Mesrine, a loyal son and dedicated soldier, is back home and living with his parents after serving in the Algerian War. Soon he is seduced by the neon glamour of sixties Paris and the easy money it presents. Mentored by Guido, Mesrine turns his back on middle class law-abiding and soon moves swiftly up the criminal ladder.

Uptight and straight-laced, FBI Special Agent Sarah Ashburn is a methodical investigator with a reputation for excellence–and hyper-arrogance. Shannon Mullins, one of Boston P.D.’s “finest,” is foul-mouthed and has a very short fuse, and uses her gut instinct and street smarts to catch the most elusive criminals. Neither has ever had a partner, or a friend for that matter. When these two wildly incompatible law officers join forces to bring down a ruthless drug lord, they become the last thing anyone expected: Buddies.

Sung-Bum (Uhm Tae-Woong) is a hot-tempered detective who relies on his intuition to crack cases. He rarely comes across a case that he cannot solve. The body of a police officer is then discovered in a burned out car near an abandoned building. Drugs are also found near the dead officer. To catch the killer the police department sets up a special investigation unit for the case. Sung-Bum takes part in the investigation. Ho-Ryong (Joo Won) is a young, confident man who works as a criminal profiler. He trained with the F.B.I. in the United States. Ho-Ryong is also assigned to the special investigation unit. Ho-Ryong relies on evidence rather than instinct. Detective Sung-Bum takes an immediate dislike for Ho-Ryong.